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Due to a rare paradoxical decrease in HDL-C seen in some patients on fenofibrate, as per US FDA label change, it is recommended that the HDL-C levels be checked within the first few months after initiation of fibrate therapy. Diet Pepsi and Diet Pepsi Classic Formula Blend (stylized as diet Pepsi CLASSIC SWEETENER BLEND ) are a no- calorie carbonated cola soft drink produced by PepsiCo, introduced in 1964 as a variant of Pepsi-Cola with no sugar. A caffeine-free version of Diet Pepsi is also produced. A powerful statin drug, cerivastatin (Lipobay), was withdrawn because of this complication. K. Clofibrate (largely obsolete due to side-effect profile, e. They are used for a range of metabolic disorders, mainly hypercholesterolemia (high cholesterol ), and are therefore hypolipidemic agents. A bottle featuring the current logo for Diet Pepsi classic sweetener blend since 2016. S. Diet Coke, Pepsi ONE, Pepsi Max, Coca-Cola Zero. The availability and brand identification of Diet Pepsi flavor variants varies by country. In some countries—primarily in Eastern Europe —the product is labeled and sold under the name Pepsi Light. Diet Coke, Pepsi ONE, Pepsi Max, Coca-Cola Zero. Since fibrates increase the cholesterol content of bile, they increase the risk for gallstones. The beverage composition, flavor variations and packaging varies based on the country of production. Most fibrates can cause mild stomach upset and myopathy (muscle pain with CPK elevations). Your daily values may be higher or lower depending on your calorie needs.
represents the largest single market for Diet Pepsi, it was launched in the U. in 1983 and has since become available on a global scale. In addition to Diet Pepsi, PepsiCo produces other low-calorie colas known as Pepsi Max and Pepsi ONE. Following a positive reception attributed to the shifting dietary habits and preferences among the Baby Boom Generation at the time, the drink was re-branded as Diet Pepsi the following year. In the 1960s and 1970s its competition consisted of Tab, produced by The Coca-Cola Company, and Diet Rite soda, produced by Royal Crown. Additional variations of Diet Pepsi have been introduced over the years, where in other flavors (such as wild cherry, vanilla, lemon, and lime) have been added to the cola. In pharmacology, the fibrates are a class of amphipathic carboxylic acids. In combination with statin drugs, fibrates cause an increased risk of rhabdomyolysis, idiosyncratic destruction of muscle tissue, leading to renal failure. In the composition of all no-calorie carbonated colas, an alternative sweetener is used in place of sugar, which if used would result in the product containing calories. Diet Pepsi was originally created in the US under the name Patio in 1963. gallstones ). While the U. If a severely depressed HDL-C level is detected, fibrate therapy should be withdrawn, and the HDL-C level monitored until it has returned to baseline. First test marketed in 1963 under the name Patio Diet Cola, it was re-branded as Diet Pepsi the following year, becoming the first diet cola to be distributed on a national scale in the United States. g. The current (aspartame-free) Diet Pepsi logo used since 2015.
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